top of page
Search

Why You Need to Detox Your Pineal Gland - Here’s How

By James Odell, OMD, ND, LAc

side profile of man's head and pineal gland

While fluoride has been praised for protecting our teeth for approximately the last 75 years, much research suggests that consuming even small amounts of it can be toxic to the human body. The biggest problem is that it can accumulate in your pineal gland - a tiny but crucial part of your brain often called the "third eye." This accumulation can potentially disrupt sleep patterns and hormone production, lower IQ, and even contribute to premature aging. In this article, we’ll explain what steps you can take to detoxify your pineal gland and restore its important function from calcification for optimal health.


Fluoride’s Toxic Effects

In recent years, several investigations have proven that fluoride from public water, toothpaste, dental treatments, and certain medications over time accumulates in the body and can induce oxidative stress causing lipid peroxidation and protein damage, as well as alter gene expression causing cellular damage and death. Aside from the toxic impact of fluoride on cellular function, it has also been shown to adversely affect neurological function lowering intelligence quotient (IQ), and interrupt the function of certain glands, particularly the thyroid and pineal. 


Dental Fluorosis

Since the 1940s we have known that the first outward manifestation of fluoride toxicity is dental fluorosis, a condition in which the teeth enamel is irreversibly damaged and discolored, forming brittle teeth that break and stain easily (see images below).


stages of dental fluorosis

levels of dental fluorosis and injested amounts

Here is the link to the Fluoride Position Paper of the International Academy of Oral Medicine and Toxicology (IAOMT). 


Fluoride’s Chemical Composition

Fluoride is related to fluorine, but the two chemicals are different as fluoride is the negative ion of the element fluorine. The symbol for the element fluorine is F whereas fluoride is often written as F-, which stands for the anion of fluorine that has a -1 electrical charge. (see halogen family below). Any compound, whether it is organic or inorganic, that contains the fluoride ion is also known as a “fluoride”. Examples include CaF2 (calcium fluoride) and NaF (sodium fluoride). Fluoride is a biological toxic halide and not an essential nutrient; no human biological process requires fluoride. 


Fluoride as a Halogen

Because of their electron configuration, the halogens are highly reactive. They readily bond with metals, particularly alkali metals. The group name “halogen” means “salt-producing” because the halogens react with metals to form salts.


Halogens are highly electronegative. Fluorine is the most electronegative halogen element. Electronegativity decreases moving down the group on the periodic table. Similarly, halogens display high electron affinities and can compete for similar cellular receptors, such as the iodine receptor on the thyroid gland.

List of the Six Halogen Elements:

  • Fluorine (F) – Atomic number 

  • Chlorine (Cl) – Atomic number 17

  • Bromine (Br) – Atomic number 3

  • Iodine (I) – Atomic number 5

  • Astatine (At) – Atomic number 85

  • Tennessine (Ts) – Atomic number 117


Halogen Family - Periodic Table

Because fluoride carries a strongly negative charge, and associates with positive sites on proteins, it interacts with metalloproteins and certain metals, particularly aluminum, forming a highly stable and often insoluble complex. Aluminum fluoride can cross the blood-brain barrier and intoxicate cells within the central nervous system. 


Anatomy and Physiology of the Pineal Gland

The pineal is a pinecone-shaped, pea-sized endocrine gland located deep in the center of the brain, between the two hemispheres. In conventional Western medicine, it is an organ primarily recognized for its role in regulating the body’s circadian rhythms and melatonin production, which helps regulate sleep-wake cycles. The pineal gland also plays a part in the body’s response to light and darkness, influencing mood, energy levels, and overall well-being. This vital gland has been called the “regulator of regulators.” While it holds significant physiological importance, some spiritual practices also attribute metaphysical qualities to the pineal gland, linking it to intuition, perception, and spiritual enlightenment.


diagram of the pineal location in the brain

In humans, the pineal gland is a neuroendocrine gland weighing about 150 mg.1 The organ, part of the epithalamus, is located between the colliculi superiores of the lamina tecti, at the back of the posterior wall of the third brain ventricle.2


The pineal gland is characterized by a vibrant network of blood vessels, which ensures blood flow of 4 mL/min/g, second only to the blood supply to the kidneys. Another unique anatomical feature of the gland is its location outside the blood-brain barrier.3, 4

Thus, being outside the blood-brain barrier (BBB) the pineal is not protected or shielded from the toxic exposure of fluoride or heavy metals. Unlike most other brain structures, the pineal gland has direct access to blood and all its components. Extremely rich vascularization and no significant restrictions in transport from the bloodstream make it possible for the pineal gland to accumulate significant amounts of calcifying substances, such as aluminum, fluoride, and calcium.5, 6, 7, 8, 9, 10, 11, 12


Cross-sectional image of the brain and the pineal gland

History of the Pineal Gland

The human pineal gland has been recognized for more than 2000 years. The Greek anatomist, Herophilus (325–280 BC), the father of anatomy described the pineal gland as a valve of animal memory. René Descartes (1596–1650), a French philosopher, mathematician, and scientist, regarded the pineal gland as the principal seat of the soul and the place in which all thoughts are formed. Hindu deities depicted with a third eye have led to the belief that the third eye—or the sixth chakra— relates to the pineal gland. According to Ayurveda, awakening your third eye can lead to increased concentration, intuitiveness, and spiritual awareness.


The Function of the Pineal Gland

A real biological function of the pineal gland was not uncovered until 1958, that is, this gland is a secretory organ that mainly produces and releases melatonin, into the blood circulation and the cerebrospinal fluid.13 In addition, it also produces some peptides14, 15 and other methylated molecules, for example, N,N-dimethyltryptamine (DMT or N,N-DMT),16, 17a potent psychedelic. This chemical was suggested to be released by the pineal gland during dreaming.18


Recently, it was reported that the pineal gland is an important organ that aids in synthesizing neurosteroids from cholesterol. These neurosteroids include testosterone, 5α- and 5β-dihydrotestosterone (5α- and 5β-DHT), 7α-hydroxypregnenolone (7α-OH PREG) and estradiol-17β. The machinery for the synthesis of these steroids has been identified in the gland. 7α-OH PREG is the major neurosteroid synthesized by the pineal gland.19 


Pineal Calcification

An intact and functional pineal gland is necessary for preserving optimal human health. Unfortunately, this gland has one of the highest calcification rates among all organs and tissues of the human body. Its malfunctions including its calcification may have associations with premature aging and aging-related diseases.


Pineal Calcification Studies

Pineal calcification is accelerated by fluoride toxicity, and this jeopardizes the gland's function and is associated with a variety of neuronal diseases. In one study it was reported that the pineal gland in a group of 45 goosanders (a type of diving duck) concentrated fluoride, which is a water pollutant.20 The level of fluoride in the pineal gland of the goosanders was 5-fold higher than in their brains. Comparable results were observed in the aged human pineal gland. 


Mrvelj and Womble conducted a study to determine the effect of fluoride removal from the diet of aged rats (over 26 months of age) on the pineal cell structure and to compare the results with rats receiving fluoride with food (control). It was observed that in animals deprived of fluoride for 8 weeks, the number of pinealocytes was higher than in control animals, which suggests a harmful effect of fluoride contained in the diet on pineal morphology and thus on the production and secretion of melatonin.


In addition, the high level of fluoride in the human pineal gland is positively related to its calcium accumulation in the gland.21 Thus, a decrease in fluoride exposure can help delay or avoid premature pineal calcification. Concentrations of fluoride in the pineal gland show inhibitory activity on melatonin synthesis pathway enzymes. Thus, the restriction of melatonin synthesis associated with pinealocyte calcification may be caused not only by a decrease in the number of active pinealocytes but also by the direct influence of fluoride accumulated in the gland on enzymatic activity.


MRI Depicting Calcified Pineal Gland

MRI Depicting Calcified Pineal


Fluoride Detoxification Protocols

Detoxification protocols for fluoride are very similar to detoxification for toxic metals. This article will next briefly outline some strategies to avoid, bind, and eliminate fluoride from the body and help decalcify the pineal gland. 


Step 1 - Eliminate All Fluoride Exposure

  • Logically, it makes sense to start first by eliminating fluoride exposure. This involves changing the water you drink to either spring, reverse osmosis, or from a filter that can remove fluoride and metals. Because we drink water (including tea and coffee) and cook with it every day, fluoridated water is the greatest source of fluoride you will most likely be exposed to throughout your entire life. This is probably the most important consideration for limiting the consumption of fluoride.  Fluoride requires a special filter to remove it from water and most do-it-yourself methods like boiling water fail to remove it.  So, double-check if your current filter can truly remove fluoride or check a brand’s performance before buying it. The safest method is to install a reverse osmosis system, which would provide you with the most reliable and cheapest source of fluoride-free water. Also, consider that many drinks such as soda, beer, and other canned or bottled beverages  may have been made with water containing fluoride. Lastly, with bottled water, fluoride is not the only thing you should worry about. Many brands may be low in fluoride but high in toxins like microplastics, PFAS, arsenic, and even high radioactivity levels.


Water filters will help you save money and provide more convenience than bottled water. The only problem is that many water filters lie about being able to remove fluoride.


  • It is imperative to avoid making infant formula with fluoridated tap water. Infant formula reconstituted with fluoridated water delivers a very high dose of fluoride to a young baby. For instance, infant formula produced with fluoridated water contains 100 to 200 times more fluoride (1,000 ppb) than is found naturally in breast milk (5-10 ppb). While breast-fed infants receive the lowest body burden (mg/kg/day) in the population, bottle-fed babies receive the highest body burden if they receive a fluoridated formula.22, 23


  • If you live in a country that allows fluoridated salt to be sold, make sure that the salt you buy is unfluoridated. Consumption of fluoridated salt can greatly increase a person's fluoride exposure.


fluoridated salt container
  • Buy and use only fluoride-free toothpaste. Fluoride toothpaste is an extremely potent source of fluoride that contains anywhere from 1000 ppm to 1500 ppm of fluoride. So, what seems like a little “pea-sized” amount of toothpaste contains a lot of fluoride. Warning labels have been added to fluoride-containing toothpaste. 


toothpaste warning label
  • Seek out a mercury-free, fluoride-free dentist. Fluoride treatments used by traditional dentists are extremely hazardous. Even though these fluoride gels are meant to be applied topically (directly to teeth), a significant amount of fluoride is absorbed into the body during treatment. Even when dentists follow safety precautions, significant ingestion can still take place. Enough to produce toxic spikes in blood fluoride levels. So next time you go to the dentist, pass on the fluoride treatment or better yet – find a fluoride-free dentist. You can find these types of dentists by searching for “fluoride-free dentists near me” using Google. But always ask because even some of these “holistic” dentists still advocate fluoride treatments and use mercury in their practice.


  • Avoid using Teflon-coated cookware. The problem is non-stick cookware like Teflon contains fluoride in the form of PFCs or Perfluorinated chemicals. This is a group of chemicals that includes PFOA, PFOS, and other per- and polyfluoroalkyl substances (PFASs). PFAS molecules contain fluorine and carbon atoms and have been shown to have a leaching effect during cooking. Instead, use cast iron or stainless steel. 


  • Avoid medication containing fluoride. Numerous medications contain fluoride. Astoundingly, 20-30% of all drugs sold contain fluoride, including some of the most well-known antidepressants and statins. Since some drugs contain fluoride, this can be a high source of daily fluoride intake, so it is best to know if your medication contains it. Consult with your doctor or pharmacist about your medications and if they contain fluoride look for alternatives or options for lowering or getting off them completely. 


For example, in 2008, these were the top ten selling drugs that contained the fluorine atom:24

Statins (Lipitor, Crestor, Vytorin, Zetia/Ezetimibe)

Anti-inflammatories (fluticasone propionate, Celebrex)

Antacids (Prevacid)

Antidepressants (Lexapro)

Neuroleptics (Risperdal)

Antibiotics (Levaquin) 


Lastly, if you are going to have surgery, ask your doctors if they can use a non-fluorinated anesthetic. Fluorinated anesthetics such as Enflurane, Isoflurane, and Sevoflurane will produce high peak levels of fluoride in the blood for up to 24 hours.


The good news is this first step is the most important – eliminating exposure to fluoride. So, if you did nothing more than step 1, you would greatly reduce fluoride accumulation over time. Once you have stopped adding fluoride to your body your body will naturally eliminate it from your body. But to go above and beyond in your fluoride detox, Step 2 will help you do exactly that.


Step 2 How to Detox Your Pineal Gland from Fluoride


Supplements for Assisting in the Elimination of Fluoride

Now that you have stopped or reduced adding fluoride to your body, it is time to  take steps to remove stored fluoride, repair any cellular damage it may have caused, so that  your pineal gland function optimally. The following nine supplements are some of the most important nutrients you can supplement to detoxify fluoride and help decalcify and regenerate the pineal gland.


1.  Zeolite

This is a rare natural mineral formed by the chemical reaction between volcanic ash and seawater. Zeolite’s detoxification benefits are due to its crystalline structure; since this is porous and negatively charged. This allows for the selective removal of toxins, especially toxic chemicals and metals, which are positively charged. Zeolite acts as a detoxification filter by binding toxins within its structure and passing them through the body via the excretory system. There are many companies selling zeolite, so it is best to do a bit of research first. The highest quality zeolite will be lab-tested, making sure to remove any pre-existing contaminants or pollutants. Furthermore, it’s best to avoid zeolites that include synthetic vitamins or other substances that can carry a positive charge, which can cause the zeolite to trap those molecules rather than the problematic toxins and metals you are trying to target. Products containing pure natural zeolite clinoptilolite are best. Additionally, particle size is a critical factor since it determines whether the zeolite will detoxify beyond the gut.


The various zeolite supplements available today include both powdered and liquid supplements. Although it may seem that it simply comes down to preference, the two have substantial differences. Firstly, powdered zeolite is often a raw substance that contains toxins naturally occurring in the environment during mining. The zeolite must undergo a liquid purification process to remove toxins so it can effectively detoxify once ingested. Secondly, purified liquid zeolite can be reduced to the nanometer particle size so it can be absorbed on a cellular level since non-micronized zeolite cannot be absorbed through water or fats. These nanometer particles are stored in liquid suspension, the preferred medium, which ensures that the zeolite can travel throughout the body for whole-body detox.25, 26, 27, 28, 29 


2. Chlorella

Chlorella (Chlorella pyrenoidosa, Chlorella vulgaris, Chlorella sorokiniana) is a freshwater green alga proven effective for binding to chemical toxins and metals and for removing heavy metal toxins from the pineal gland. Chlorella has a long history of use as a food source and contains a unique and diverse composition of functional macro- and micro-nutrients including proteins, omega-3 polyunsaturated fatty acids, polysaccharides, vitamins, and minerals.30, 31, 32, 33


In scientific literature, the total daily dose of chlorella ranges from 6 to 10 grams per day. Chlorella is best used in short cycles, generally no longer than two months at a time, rest a month, and repeat.


3. Iodine

Iodine has been clinically proven to increase the removal of sodium fluoride from the body via urine as calcium fluoride. As a halide-like fluorine, supplementing the body with iodine displaces fluoride from cell receptors and flushes the fluoride out of the body in urine. Seaweed is a great source of natural iodine. 


For seaweed and kelp, try to purchase them from Icelandic sources. This region is the furthest from Fukushima and therefore is said to have the least radiation from the nuclear reactor explosion. Seaweeds are low sources of iodine so you might also want to consider taking supplemental iodine (such as Lugol’s 2%) . There are two main “raw” forms of iodine used for health—elemental iodine (I2) and potassium iodide (KI). Any of the forms we want to use for healing will contain either or both along with distilled water. Lugol’s is 1-part elemental iodine(I2) and 2-parts potassium iodide and water. Please do not overdo it with iodine. Do your research; only a small amount each day is required.34, 35, 36


4. Boron

Boron is another effective fluoride detoxifier and pineal gland cleanser. Scientific studies in Germany (in pigs)37 and China (in humans) reveal the level of effectiveness of using boron to detox fluoride in extreme cases of skeletal fluorosis.38, 39 


Marcovitch and Stanley initiated studies in 1942 on identifying antidotes for fluorine.40 Their evidence revealed that boric acid, a compound derived from boron, had value as an antidote because it combined with fluoride to form a fluoborate that could be excreted in the urine. Other studies have demonstrated the effectiveness of boron on fluoride excretion.41, 42, 43 


The lowest active dose of boron supplementation appears to be 3 mg, which is effective in supporting hormonal parameters in postmenopausal women. Studies on osteoarthritis have used 6mg of boron. Generally, dosages of 2 to 6 mg of boron appear to be safe and effective to detox your pineal gland of fluoride. Avocados, beets, prunes, raisins, almonds, hazelnuts, and dates are naturally high sources of boron and can be eaten daily as a source.


5. Methylsulfonylmethane (MSM)

MSM a naturally occurring organosulfur compound with broad biological effects. This is a form of sulfur that is a substrate for the all-important sulfation process, essential for the detoxification of many chemicals. Sulfation is a conjugation process, and it is involved in important biochemical activities from the biotransformation/detox pathways to the biosynthesis of some proteins.  Sulfation is engaged in detoxification, hormone regulation, molecular recognition, cell signaling, and viral entry into cells. Sulfation is an important pathway in the biotransformation of numerous xenobiotics (foreign or exogenous substances) such as drugs, chemicals (fluoride), and toxic metals. MSM is well-tolerated by most individuals at dosages of up to three grams daily, with few known and mild side effects. Most physicians recommend starting with 1500 to 2000 milligrams daily, taking a little bit with each meal, and working your way up to 3000.


Another wonderful source of sulfur is garlic. It is also great at cleansing the body of pathogenic organisms and improving cardiovascular function due to its anti-atherosclerotic effect.44, 45, 46, 47, 48 


You only need to consume about half a bulb to two bulbs daily. Make sure it is organic and that you chop it up and let it sit for at least 15 minutes before consuming it. A diet rich in allium vegetables (garlic, chives, leeks, onions, rakkyo, scallions, and shallots) is a great source of sulfur and can deliver delicious flavor and excellent beneficial compounds to the diet. 


6.  Fish Oil

 It is important to purchase only pharmaceutical-quality fish oil and check the expiration date. One excellent product is organic blue ice fermented skate fish oil. Fish oil contains the essential fatty acids DHA and EPA and fat-soluble vitamins that are critical for nervous system regeneration. For those who are not able to consume fish oil, algae oil is an excellent substitute.


7. Tamarind

Tamarind (Tamarindus indica), is a leguminous tree-bearing edible fruit that is indigenous to tropical Africa and naturalized in Asia. Research suggests that tamarind fruit and leaves accelerate the excretion of fluoride in urine. In one study researchers found that tamarind leaves to be antihyperglycaemic, antihyperlipidaemic, antiperoxidative, and an antioxidant agent in fluoride-induced toxicity.49, 50


By eating tamarind fruit or drinking tamarind tea, you can help your body release the fluoride hiding in the pineal gland and nooks and crannies of your internal systems. Organic tamarind products are hard to come by in the States, one source is Rani’s Non-GMO Tamarind paste.


8. Amla (Emblica officinalis) 

Amia or Indian gooseberry. Amla is also an incredibly potent natural medicine, prominently featured in Ayurvedic medicine. Scientists have confirmed several powerful medicinal uses for amla, particularly useful for detoxification. Amla has been considered to exert potential therapeutic effects in neurodegenerative disorders due to its complementary antioxidant and anti-inflammatory properties. Specifically, studies of amla in combination with melatonin have ameliorative effects against fluoride-induced genotoxicity, making the cell cycle kinetics and sister chromatid exchanges(SCEs) frequency comparable to those in control cultures.51, 52, 53 


A good starting dose of amla powder is between 1 tsp and 1 tbsp, taken once a day either with food or drink. However, if you do not have a bleeding disorder you can add amla to pretty much every meal of the day with no side effects.


9.  Fulvic Acid and Humic Acid 

Fulvic acid and humic acid are powerful (and natural) substances that you can use to detox the body of toxins and heavy metals, while also providing the body with well-needed antioxidants that balance the endocrine system. Fulvic and humic acids have been shown to contain multiple active functional groups, including phenolic hydroxyl, ketone carbonyl, quinone carbonyl, carboxyl, and alkoxyl groups. Their structure is made up of aromatic, organic polymers with many carboxyl groups that release hydrogen ions, resulting in an electric charge that helps attract free radicals, heavy metals, and other toxins within the body. This allows it to act like a detoxification agent. Once it becomes reactive with metals, these organic acids help them become more soluble in water, which means they are carried out of the body more easily.54, 55, 56


Both can be taken in supplement form, or they can be found in shilajit, a natural substance that forms in rocks in the Himalayas thanks to the extremely slow (we’re talking centuries here) decomposition of plants. Thus, shilajit is an excellent source of these unique organic acids. Authentic shilajit comes in the form of thick, sticky goo. You dissolve it in a small amount of warm water before drinking it.


Other Considerations

  • Improve Your Diet

Eating foods that are high in antioxidants, minerals, and vitamins can combat calcification of the pineal gland. Maintaining a healthy balanced diet, choosing organic food when possible, and eating proper portions are key to getting your body the nutrients it needs to function. Some of the best foods to combat pineal gland calcification are: seaweed, beets and beet juice, garlic, leafy greens, and greens high in chlorophyll and vitamins K1 and K2 (chlorella, wheatgrass, blue-green algae, spinach, parsley, cilantro, collard greens, arugula, broccoli), medicinal mushrooms (chaga, cordyceps, shitake, maitake). 


  • Exercise

Exercise improves circulation and helps you sweat, which is one of the best ways to remove toxins from the body. Whether you want to do this through free-weight training, hot yoga, dance or aerobic exercise is up to you, this helps the body eliminate toxins. Keep in mind that the best exercise or gym routine is one you enjoy and can do consistently. The goal here is to be and stay active and be regular.


  • Sauna

A sauna's dry heat (which can get as high as 185° F) has profound effects on the body. Skin temperature soars to about 104° F within minutes. The average person will pour out a pint of sweat during a short stint in a sauna. Sauna therapy increases metabolism, assists with weight loss, and detoxifies the body. The pulse rate may increase by 30% or more, allowing the heart to nearly double the amount of blood it pumps each minute. Most of the extra blood flow is directed to the skin as the circulation shunts blood away from the internal organs. Saunas are generally safe for most people. However, people with uncontrolled high blood pressure and heart disease should check with their doctors before taking a sauna.57


  • Avoid Blue Light Before Sleep

The pineal gland is very reactive to different light spectra.58 Light suppresses melatonin in humans, with the strongest response occurring in the short-wavelength portion of the spectrum between 446 and 477 nm that appears blue.59 Thus, blue light frequency before bed can disrupt the circadian rhythm and disturb sleep. LED technology has become a greater presence in our homes, work, and general environment. With narrow-bandwidth blue LEDs and blue-enriched white, broadband LEDs, there is also some concern about ocular safety with extended exposure to these light sources.60 


Blue light is what comes from our phones, TVs, and electronics. Taking your phone to bed or watching TV shortly before sleep can disrupt your sleep/wake cycle. Best to put electronics away an hour or so before going to bed, and wind down by reading a book or listening to soothing music.


  • EDTA IV Chelation

In standard medical practice, certain medications (also known as ‘chelants’) are used in specific situations to help remove excessive levels of certain toxic metals from the body. The chelators bind to these metals in the blood and some body tissues causing them to be more quickly eliminated in the urine or stool. Whether the chelation medication is swallowed, or injected into the muscle or vein, depends on the type of chelation medication used and the medical situation of the patient being treated. Some practitioners of complementary medicine use medications or natural products, labeled as chelators, to treat a variety of chronic medical conditions. Many of the previously mentioned supplements can be considered chelators. 


One proven chelator for binding metals and helping remove arterial plaque and calcifications is Ethylenediaminetetraacetic acid (EDTA).61, 62, 63, 64, 65 

EDTA chelation therapy is commonly used to treat atherosclerosis and relieve symptoms of cardiovascular disease. EDTA is also widely used in the management and treatment of heavy metal toxicity. Edetate disodium chelates lead and cadmium and allows their efficient removal by renal excretion, especially lead and cadmium toxicity.66, 67, 68 This solution can dissolve the calcium deposits in arteries as well as  in the pineal gland.

EDTA chelation is a safe, relatively inexpensive, non‐surgical method of restoring blood flow in atherosclerotic vessels affected by calcification and plaque. Thus, preventing chronic symptoms such as angina pectoris and claudication, or acute events such as myocardial infarction or stroke.69


Several clinics have been set up worldwide offering it to people with atherosclerotic cardiovascular disease. EDTA is rarely used in isolation, except perhaps for heavy metal poisoning. Most practitioners who offer intravenous EDTA treatments utilize it as a part of a comprehensive therapy program. They reject the prevailing opinion that a systemic disease like atherosclerosis can only be effectively treated with surgical interventions. Likewise, these practitioners prefer to minimize the use of pharmaceutical agents that can both interfere with biochemical pathways and enzyme systems and often result in unwanted side effects. While EDTA is certainly a medication with potential side effects, it is extremely safe if used according to accepted protocols. Usually, oral, and intravenous antioxidants are given with chelation therapy, especially vitamins C, glutathione, and alpha lipoic acid.70, 71, 72 


Treatment is aimed at removing accumulations in the body of harmful levels of aluminum, lead, and other toxic heavy metals, all of which enhance free radical damage. Treatment objectives also include the removal of calcium plaque from arteries and soft tissues, enhancement of the levels of ionic magnesium intracellularly, and reduction of pathologically enhanced clotting mechanisms, especially platelet adhesiveness. Thus, for those individuals with serious calcifications of the pineal, intravenous EDTA may also be helpful. 


  • Frequency Therapy

Lastly, for those utilizing bio-frequency therapy, it is observed that the frequency of 20 Hz stimulates the pineal gland. 963 Hz to pineal frequency at end of articleThere is a YouTube video of 20 Hz available for those interested in sound therapy for the pineal.73


Conclusion

As previously described in the article Fluoride Toxicity published in the 45th BRMI E-Journal,fluoride is a cellular toxin. 


Over time fluoride accumulates in the body and can lead to the inhibition of numerous critical proteins, a release of free radicals, a disruption of metal homeostasis, a disruption in pH (acidification of the extracellular matrix), and damage to tissue-organs and glands. Fluoride enters the body mostly from municipal water sources that have been fluoridated and drinks that use public water in their manufacturing process. Dental treatments and toothpaste also account for some contamination as well. The degree of toxicity is determined by how much fluoride a person consumes during their lifetime, as well as their genomic profile’s ability to detoxify this element. Fluoride toxicity is associated with pineal gland calcification. The preservation of pineal health can be achieved by retarding its premature calcification through fluoride elimination and detoxification or even rejuvenating the calcified gland.


References

  1. Golan, J.; Torres, K.; Staśkiewicz, G.J.; Opielak, G.; Maciejewski, R. Morphometric parameters of the human pineal gland in relation to age, body weight and height. Folia Morphol. 200261, 111–113.

  2. Macchi, M.M.; Bruce, J.N. Human pineal physiology and functional significance of melatonin. Front. Neuroendocrinol. 200425, 177–195.

  3. Macchi, M.M.; Bruce, J.N. Human pineal physiology and functional significance of melatonin. Front. Neuroendocrinol. 200425, 177–195.

  4. Arendt, J. Melatonin and the Mammalian Pineal Gland, 1st ed.; Chapman & Hall: London, UK, 1995; p. 17.]

  5. Mahlberg, R.; Kienast, T.; Hödel, S.; Heidenreich, J.O.; Schmitz, S.; Kunz, D. Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Med. 200910, 439–445.

  6. Patel, S.; Rahmani, B.; Gandhi, J.; Seyam, O.; Joshi, G.; Reid, I.; Smith, N.L.; Waltzer, W.C.; Khan, S.A. Revisiting the pineal gland: A review of calcification, masses, precocious puberty, and melatonin functions. Int. J. Neurosci. 202025, 1–12.

  7. Tan, D.-X.; Xu, B.; Zhou, X.; Reiter, R.J. Calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland. Molecules 201823, 301.

  8. Kiroğlu, Y.; Çalli, C.; Karabulut, N.; Oncel, C. Intracranial calcifications on CT. Diagn. Interv. Radiol. 201016, 263–269.

  9. McKinney, A.M. Atlas of Normal Imaging Variations of the Brain, Skull, and Craniocervical Vasculature; Springer International Publishing: Cham, Switzerland, 2017.

  10. Luke, J. Fluoride deposition in the aged human pineal gland. Caries Res. 2001, 35, 125–128.

  11. Tharnpanich, T.; Johns, J.; Subongkot, S.; Johns, N.P.; Kitkhuandee, A.; Toomsan, Y.; Luengpailin, S. Association between high pineal fluoride content and pineal calcification in a low fluoride area. Fluoride 2016, 49, 472–484.

  12. Luke, J. The Effect of Fluoride on the Physiology of the Pineal Gland. Ph.D. Thesis, University of Surrey, Guildford, UK, 1997. 

  13. Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc. 1958, 80, 2587.

  14. Pavel, S.; Petrescu, S. Inhibition of gonadotrophin by a highly purified pineal peptide and by synthetic arginine vasotocin. Nature 1966, 212, 1054. 

  15. Khavinson, V.K.; Kopylov, A.T.; Vaskovsky, B.V.; Ryzhak, G.A.; Lin’kova, N.S. Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland. Bull. Exp. Biol. Med. 2017, 164, 41–43. 

  16. Hill, D.R.; Persinger, M.A. Application of transcerebral, weak (1 microT) complex magnetic fields and mystical experiences: Are they generated by field-induced dimethyltryptamine release from the pineal organ? Percept. Mot. Skills 2003, 97, 1049–1050.

  17.  Guchhait, R.B. Biogenesis of 5-methoxy-N,N-dimethyltryptamine in human pineal gland. J. Neurochem. 1976, 26, 187–190.

  18. Nichols, D.E. N,N-dimethyltryptamine and the pineal gland: Separating fact from myth. J. Psychopharmacol. 2017, 32, 30–36.

  19. Tsutsui, K.; Haraguchi, S.; Vaudry, H. 7α-Hydroxypregnenolone regulating locomotor behavior identified in the brain and pineal gland across vertebrates. Gen. Comp. Endocrinol. 2017

  20. Kalisinska, E.; Bosiacka-Baranowska, I.; Lanocha, N.; Kosik-Bogacka, D.; Krolaczyk, K.; Wilk, A.; Kavetska, K.; Budis, H.; Gutowska, I.; Chlubek, D. Fluoride concentrations in the pineal gland, brain and bone of goosander (Mergus merganser) and its prey in Odra River estuary in Poland. Environ. Geochem. Health 2014, 36, 1063–1077.

  21. Luke, J. Fluoride deposition in the aged human pineal gland. Caries Res. 2001, 35, 125–128.

  22. https://reference.medscape.com/drug/enfamil-isomil-infant-formula-344452

  23. https://www.mayoclinic.org/healthy-lifestyle/infant-and-toddler-health/in-depth/infant-formula/art-20045791?pg=2

  24. Wang, Qian, Yeping Bian, Gagan Dhawan, Wei Zhang, Alexander E. Sorochinsky, Ata Makarem, Vadim A. Soloshonok, and Jianlin Han. "FDA approved fluorine-containing drugs in 2023." Chinese Chemical Letters (2024): 109780.

  25. Ignatov, Ignat, and Yuliana Pesheva. "ZEOLITH Detox for Detoxification of Human Body. Proofs for Anti Inflammatory Effects of Zeolite and Detoxification." European Journal of Molecular Biotechnology 6 (2018): 41-52.

  26. Motsi, T., N. A. Rowson, and M. J. H. Simmons. "Adsorption of heavy metals from acid mine drainage by natural zeolite." International journal of mineral processing 92, no. 1-2 (2009): 42-48.

  27. Ok, Yong Sik, Jae E. Yang, Yong-Seon Zhang, Su-Jung Kim, and Doug-Young Chung. "Heavy metal adsorption by a formulated zeolite-Portland cement mixture." Journal of Hazardous Materials 147, no. 1-2 (2007): 91-96.

  28. Rad, Leila Roshanfekr, and Mansoor Anbia. "Zeolite-based composites for the adsorption of toxic matters from water: A review." Journal of Environmental Chemical Engineering 9, no. 5 (2021): 106088.

  29. Mo, Zhenlin, DeZhi Tai, Hua Zhang, and Asfandyar Shahab. "A comprehensive review on the adsorption of heavy metals by zeolite imidazole framework (ZIF-8) based nanocomposite in water." Chemical Engineering Journal 443 (2022): 136320.

  30. Rani, Komal, Nidhi Sandal, and P. K. Sahoo. "A comprehensive review on chlorella-its composition, health benefits, market and regulatory scenario." The Pharma Innovation Journal 7, no. 7 (2018): 584-589.

  31. Bito, Tomohiro, Eri Okumura, Masaki Fujishima, and Fumio Watanabe. "Potential of Chlorella as a dietary supplement to promote human health." Nutrients 12, no. 9 (2020): 2524.

  32. Tang, Guangwen, and Paolo M. Suter. "Vitamin A, nutrition, and health values of algae: Spirulina, Chlorella, and Dunaliella." Journal of Pharmacy and Nutrition Sciences 1, no. 2 (2011): 111-118.

  33. Vojvodić, Snežana, Marina Stanić, Bernd Zechmann, Tanja Dučić, Milan Žižić, Milena Dimitrijević, Jelena Danilović Luković, Milica R. Milenković, Jon K. Pittman, and Ivan Spasojević. "Mechanisms of detoxification of high copper concentrations by the microalga Chlorella sorokiniana." Biochemical Journal 477, no. 19 (2020): 3729-3741.

  34. Susheela, Andezhath K. "Fluorosis and iodine deficiency disorders in India." Current Science 115, no. 5 (2018): 860-867.

  35. Bürgi, H., L. Siebenhüner, and E. Miloni. "Fluorine and thyroid gland function: a review of the literature." Klinische Wochenschrift 62 (1984): 564-569.

  36. Zhao, W., H. Zhu, Z. Yu, K. Aoki, J. Misumi, and X. Zhang. "Long-term effects of various iodine and fluorine doses on the thyroid and fluorosis in mice." Endocrine regulations 32, no. 2 (1998): 63-70.

  37. Seffner, W., and W. Teubener. "Antidotes in experimental fluorosis on pigs morphological studies." (1983): 33-37.

  38. Liu, Y., & Min, Z. (1999). Study of strontium and boron as antidotes to fluoride toxicity. Toxicological & Environmental Chemistry70(1-2), 1-7.

  39. Li, Jian, Hui Zhang, Jingjing Zhang, Qinggui Xiao, Xuan Du, and Tao Qi. "Efficient removal of fluoride by complexation extraction: mechanism and thermodynamics." Environmental Science & Technology 53, no. 15 (2019): 9102-9108.

  40. MARCOVITCH, S. "THE TOLERANCE ON FLUORINE AND CRYOLITE SPRAY RESIDUE." In Proceedings of the Sixth Pacific Science Congress of the Pacific Science Association, vol. 1, p. 125. Univ of California Press, 1940.

  41. Seflner, W., W. Teubener, H. Runde, H. Wiedner, J. Vogt, KEthen Leipzig, and G. D. R. Bitterfeld. "BORON AS AN ANTIDOTE TO FLUOROSIS?." FLUORIDE: 68.

  42. J. Elsair and his fellow researchers noted in their study that boron increased urinary fluoride excretion.

  43. Elsair, J., R. Merad, R. Denine, M. Reggabi, B. Alamir, S. Benali, M. Azzouz, and K. Khelfat. "Boron as a preventive antidote in acute and subacute fluoride intoxication in rabbits: its action on fluoride and calcium-phosphorus metabolism." (1981): 129-138.

  44. Koch HP, Lawson LD. Garlic: the science and therapeutic application of Allium sativum L. and related species. 2d ed. Baltimore: Williams & Wilkins, 1996.

  45. Koscielny J, Klussendorf D, Latza R, Schmitt R, Radtke H, Siegel G, et al. The antiatherosclerotic effect of Allium sativum. Atherosclerosis 1999;144:237-49.

  46. Siegel G, Klussendorf D. The anti-atherosclerotic effect of Allium sativuum: statistics re-evaluation. Atherosclerosis 2002;150:437-8. 

  47. Breithaupt-Grogler K, Ling M, Boudoulas H, Belz GG. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation 1997;96: 2649-55. 

  48. Warshafsky S, Kamer RS, Sivak SL. Effect of garlic on total serum cholesterol. A meta-analysis. Ann Intern Med 1993;119(7 pt 1):599-605. 

  49. Vasant, Rupal A., and A. V. R. L. Narasimhacharya. "Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations." Environmental health and preventive medicine 17 (2012): 484-493.

  50. Ameeramja, Jaishabanu, Azhwar Raghunath, and Ekambaram Perumal. "Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats." Environmental Science and Pollution Research 25 (2018): 26157-26166.

  51. Husain, Ibraheem, Saima Zameer, Tushar Madaan, Akram Minhaj, Wasim Ahmad, Asif Iqubaal, Abuzer Ali, and Abul Kalam Najmi. "Exploring the multifaceted neuroprotective actions of Emblica officinalis (Amla): a review." Metabolic brain disease 34 (2019): 957-965.

  52. Singh, Inder, Abhilasha Sharma, Archana Jindal, Dhanraj Soyal, and P. K. Goyal. "Fruit extract of Emblica officinalis (amla) protects radiation induced biochemical lesions in the brain of Swiss albino mice." Annals of Neurosciences 13, no. 3 (2010): 65-71.

  53. Rose, Kenneth, Chunpeng Wan, Amber Thomas, Navindra P. Seeram, and Hang Ma. "Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities." Natural Product Communications 13, no. 10 (2018): 1934578X1801301019.

  54. Gaffney, Jeffrey S., Nancy A. Marley, and Sue B. Clark. "Humic and fulvic acids and organic colloidal materials in the environment." 1996.

  55. Papadaki, Eirini S., Theodoros Chatzimitakos, Vassilis Athanasiadis, Dimitrios Kalompatsios, Eleni Bozinou, Paraskevi Mitlianga, and Stavros I. Lalas. "Assessment of Humic and Fulvic Acid Sorbing Potential for Heavy Metals in Water." Foundations 3, no. 4 (2023): 788-804.

  56. De Paolis, Fabrizio, and Jussi Kukkonen. "Binding of organic pollutants to humic and fulvic acids: influence of pH and the structure of humic material." Chemosphere 34, no. 8 (1997): 1693-1704.

  57. Crinnion, Walter. "Components of practical clinical detox programs–sauna as a therapeutic tool." Alternative Therapies in Health and Medicine 13, no. 2 (2007): S154-S156.

  58. Aral, Erinc, Sema Uslu, Emine Sunal, Ayla Eker Sariboyaci, Imer Okar, and Ertunc Aral. "Response of the pineal gland in the rats exposed to three different light spectra of short periods." Turkish Journal of Veterinary & Animal Sciences 30, no. 1 (2006): 29-34.

  59. West, Kathleen E., Michael R. Jablonski, Benjamin Warfield, Kate S. Cecil, Mary James, Melissa A. Ayers, James Maida et al. "Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans." Journal of applied physiology (2011).

  60. Bullough, John D. "The blue-light hazard: A review." Journal of the Illuminating Engineering Society 29, no. 2 (2000): 6-14.

  61. Halstead BM. The Scientific Basis of EDTA Chelation Therapy. Colton, CA: Golden Quill Publishers; 1979:5-15.

  62. Chappell LT, Janson MJ. EDTA chelation therapy in the treatment of vascular disease. J Cardiovasc Nurs 1996;10:78-86. Clarke NE, Clarke CN, Mosher RE. The “in vivo” dissolution of metastatic calcium: an approach to atherosclerosis. Am J Med Sci 1955;229:142-149. 

  63. Clarke NE. Treatment of angina pectoris with disodium EDTA. AM J Med Sci 1956;232:654666. Clarke NE. Atherosclerosis, occlusive vascular disease and EDTA. Am J of Cardiol 1960;6:233.

  64. Kitchell JR, Meltzer LE, Seven MJ. Potential uses of chelation methods in the treatment of cardiovascular diseases. Prog Cardio Dis 1961;3:338-349.

  65. Casdorph HR. EDTA chelation therapy, efficacy in arteriosclerotic heart disease. J Hol Med 1981;3:53-59.

  66. Olszewer E, Carter JP. EDTA chelation therapy in chronic degenerative disease. Med Hypoth 1988;27:41-49. 

  67. Ernst, E. "Chelation therapy for peripheral arterial occlusive disease: a systematic review." Circulation 96, no. 3 (1997): 1031-1033.

  68. Hiatt, William R. "Current and future drug therapies for claudication." Vascular Medicine 2, no. 3 (1997): 257-262.

  69. McDonagh EW, Rudolph CJ, Cheraskin E. The psychotherapeutic potential of EDTA chelation. J Orthomol Psych 1984;14:214-217. 

  70. McDonagh EW, Rudolph CJ, Cheraskin E. The “clinical change” in patients treated with EDTA chelation plus multivitamin/trace mineral supplementation upon reported fatigue. J Orthomol Psych 1985;14:1-5. 

  71. McDonagh EW, Rudolph CJ, Cheraskin E. The effect of EDTA chelation therapy with multivitamin/trace mineral supplementation upon reported fatigue. J Orthomol Psych 1983;13:13.

  72. Lamas GA, Boineau R, Goertz C, et al. EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy. Am Heart J 2014;168:37-44.e5.

  73.  https://www.youtube.com/watch?v=Oq4v2Z22nCk


BRMI logo

Bioregulatory medicine is a total body (and mind) approach to health and healing that aims to help facilitate and restore natural human biological processes. It is a proven, safe, gentle, highly effective, drugless, and side-effect-free medical model designed to naturally support the body to regulate, adapt, regenerate, and self-heal. BRMI is a non-commercial 501(c)(3) foundation and will expand and flourish with your support. Our goal is to make bioregulatory medicine a household term.


This article is for informational purposes only and is not intended to be a substitute for the direct care of a qualified health practitioner who oversees and provides unique and individualized care. The information provided here is to broaden our different perspectives and should not be construed as medical advice, diagnosis, or treatment. 

THE CONTENT ON THIS SITE IS PRESENTED IN SUMMARY FORM, IS GENERAL IN NATURE, AND IS PROVIDED FOR INFORMATIONAL PURPOSES ONLY; IT IS NOT ADVICE, NOR SHOULD IT BE TREATED AS SUCH. If you have any healthcare-related concerns, please call or see your physician or other qualified healthcare provider. This site is NOT intended to be a substitute for a healthcare provider’s consultation: NEVER DISREGARD MEDICAL ADVICE OR DELAY IN SEEKING IT BECAUSE OF SOMETHING YOU HAVE SEEN ON THIS SITE. We make no representations, nor any warranties, nor assume any liability for the content herein; nor do we endorse any particular product, provider, or service.

  • Facebook
  • Instagram
  • LinkedIn
  • Twitter
  • YouTube

© 2017-2024 Dr. James Odell, ND, OMD, L.Ac. 

bottom of page